Southern Africa has an excellent infrastructure. The airports are modern and efficiently run, and the staff there are all very “visitor friendly”. You will be met at the airport by your guide and will be delivered back there, safe and sound. Most visitors will require no other travel document than their passport. There are no visa requirements for visitors from the USA. The roads are in excellent repair and travel around the area is no problem. Most travel is by road. Just keep in mind that Southern Africa is a vast area (the countries will cover the entire Eastern Seaboard of the USA) so travel takes up a lot of time. The countryside is spectacular, though, so you are not likely to get bored.